erratumScientific ReportsJan 21, 2016GOLD OA

Correction: Corrigendum: Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

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Abstract

Aging is one of the most important biological processes and is a known risk factor for many age-related diseases in human. Studying age-related transcriptomic changes in tissues across the whole body can provide valuable information for a holistic understanding of this fundamental process. In this work, we catalogue age-related gene expression changes in nine tissues from nearly two hundred individuals collected by the Genotype-Tissue Expression (GTEx) project. In general, we find the aging gene expression signatures are very tissue specific. However, enrichment for some well-known aging components such as mitochondria biology is observed in many tissues. Different levels of cross-tissue synchronization of…

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Authors

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Topics & keywords

Keywords
  • Transcriptome
  • Gene expression
  • Biology
  • Gene
  • Regulation of gene expression
  • Computational biology
  • Gene expression profiling
  • Biological age
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