Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

Non-coding RNAs do not encode proteins and regulate various oncological processes. They are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics and translation omics have begun to elucidate the roles and modes of action of the functional peptides encoded by ncRNA. Here, recent advances in long non-coding RNA (lncRNA) and circular RNA (circRNA)-encoded small peptides are compiled and synthesized. We introduce both the computational and analytical methods used to forecast prospective ncRNAs encoding oncologically functional oligopeptides. We also present numerous specific lncRNA and circRNA-encoded proteins and their cancer-promoting or cancer-inhibiting molecular mechanisms.…

• CI
  Centre International de Recherche sur le Cancer
• NN
  National Natural Science Foundation of China

  Awards: 81702907, 81872278, 2018SK21210, 81903138, 81972776, 2018JJ3815, 81672683, 81803025, 81772928, 81672993, 81772901, 2018SK21211, 2018JJ3704
• CS
  Central South University
• NS
  Natural Science Foundation of Hunan Province

  Awards: 2018SK21211, 2018SK21210, 2018JJ3704, 2019JJ50778, 2018JJ3815
• HP
  Hunan Provincial Innovation Foundation for Postgraduate

  Awards: CX20190234, CX20190235
• FR
  Fundamental Research Funds for Central Universities of the Central South University

  Awards: 2019zzts890, 2019zzts179, 2019zzts178