Proteogenomic Characterization of Endometrial Carcinoma
Baylor College of Medicine · Institute for Systems Biology · +23 more institutions
Abstract
We undertook a comprehensive proteogenomic characterization of 95 prospectively collected endometrial carcinomas, comprising 83 endometrioid and 12 serous tumors. This analysis revealed possible new consequences of perturbations to the p53 and Wnt/β-catenin pathways, identified a potential role for circRNAs in the epithelial-mesenchymal transition, and provided new information about proteomic markers of clinical and genomic tumor subgroups, including relationships to known druggable pathways. An extensive genome-wide acetylation survey yielded insights into regulatory mechanisms linking Wnt signaling and histone acetylation. We also characterized aspects of the tumor immune landscape, including immunogenic…
Citation impact
- FWCI
- 29.42
- Percentile
- 100%
- References
- 194
Authors
218- YDYongchao Dou
Baylor College of Medicine
- EKEmily Kawaler
Institute for Systems Biology, New York University
- DCDaniel Cui Zhou
James S. McDonnell Foundation, Washington University in St. Louis
- MAMarina A. Gritsenko
Pacific Northwest National Laboratory
- CHChen Huang
Baylor College of Medicine
Topics & keywords
- Biology
- Druggability
- Wnt signaling pathway
- Immune system
- Epigenetics
- Computational biology
- Cancer research
- Tumor microenvironment
- Good health and well-being