The 2018 World Health Organization Classification of Cutaneous, Mucosal, and Uveal Melanoma: Detailed Analysis of 9 Distinct Subtypes Defined by Their Evolutionary Pathway
University of California, San Francisco · Royal Prince Alfred Hospital · +3 more institutions
Abstract
Context.— There have been major advances in the understanding of melanoma since the last revision of the World Health Organization (WHO) classification in 2006. Objective.— To discuss development of the 9 distinct types of melanoma and distinguishing them by their epidemiology, clinical and histologic morphology, and genomic characteristics. Each melanoma subtype is placed at the end of an evolutionary pathway that is rooted in its respective precursor, wherever appropriate and feasible, based on currently known data. Each precursor has a variable risk of progression culminating in its fully evolved, invasive melanoma. Data Sources.— This review is based on the “Melanocytic Tumours” section of the 4th edition…
Citation impact
- FWCI
- 21.98
- Percentile
- 100%
- References
- 188
Authors
5- DEDavid E. ElderCorresponding
University of California, San Francisco, Royal Prince Alfred Hospital, Hospital of the University of Pennsylvania, Centre international de recherche sur le cancer, University of Florence
- BCBoris C. Bastian
University of California, San Francisco, Royal Prince Alfred Hospital, Hospital of the University of Pennsylvania, Centre international de recherche sur le cancer, University of Florence
- IAIan A. Cree
University of California, San Francisco, Royal Prince Alfred Hospital, Hospital of the University of Pennsylvania, Centre international de recherche sur le cancer, University of Florence
- DMDaniela Massi
University of California, San Francisco, Royal Prince Alfred Hospital, Hospital of the University of Pennsylvania, Centre international de recherche sur le cancer, University of Florence
- RARichard A. Scolyer
University of California, San Francisco, Royal Prince Alfred Hospital, Hospital of the University of Pennsylvania, Centre international de recherche sur le cancer, University of Florence
Topics & keywords
- Melanoma
- Mucosal melanoma
- Medicine
- Pathology
- Biology
- Dermatology
- Cancer research
- Good health and well-being