reviewAnnual Review of PhysiologyFeb 10, 2020BRONZE OA

The Osteocyte: New Insights

AGAlexander G. RoblingLFLynda F. Bonewald

Indiana University School of Medicine · Indiana University – Purdue University Indianapolis

PubMed
Indexed incrossrefpubmed

Abstract

Osteocytes are an ancient cell, appearing in fossilized skeletal remains of early fish and dinosaurs. Despite its relative high abundance, even in the context of nonskeletal cells, the osteocyte is perhaps among the least studied cells in all of vertebrate biology. Osteocytes are cells embedded in bone, able to modify their surrounding extracellular matrix via specialized molecular remodeling mechanisms that are independent of the bone forming osteoblasts and bone-resorbing osteoclasts. Osteocytes communicate with osteoclasts and osteoblasts via distinct signaling molecules that include the RankL/OPG axis and the Sost/Dkk1/Wnt axis, among others. Osteocytes also extend their influence beyond the local bone…

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Topics & keywords

Topics
Keywords
  • Osteocyte
  • Cell biology
  • Bone cell
  • Sclerostin
  • Chemistry
  • Bone remodeling
  • Context (archaeology)
  • Wnt signaling pathway
UN Sustainable Development Goals
  • Life below water
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