Near-Infrared Light-Triggered Nitric-Oxide-Enhanced Photodynamic Therapy and Low-Temperature Photothermal Therapy for Biofilm Elimination

Zhang, Yuan; Lin, Chuanchuan; He, Ye; Tao, Bailong; Chen, Maowen; Zhang, Jixi; Liu, Peng; Cai, Kaiyong

doi:10.1021/acsnano.9b09871

articleACS NanoFeb 18, 2020Closed access

Near-Infrared Light-Triggered Nitric-Oxide-Enhanced Photodynamic Therapy and Low-Temperature Photothermal Therapy for Biofilm Elimination

YZYuan Zhang CLChuanchuan Lin YHYe He BTBailong Tao MCMaowen Chen

Chongqing University · Southwest University

PubMed

Indexed incrossrefpubmed

Abstract

Photothermal treatment (PTT) involving a combination of therapeutic modalities recently emerged as an efficient alternative for combating biofilm. However, PTT-related local high temperature may destroy the surrounding healthy tissues. Herein, we present an all-in-one phototherapeutic nanoplatform consisting of l-arginine (l-Arg), indocyanine green (ICG), and mesoporous polydopamine (MPDA), namely, AI-MPDA, to eliminate the already-formed biofilm. The fabrication process included surface modification of MPDA with l-Arg and further adsorption of ICG via π–π stacking. Under near-infrared (NIR) exposure, AI-MPDA not only generated heat but also produced reactive oxygen species, causing a cascade catalysis of…

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Topics & keywords

Topics

Keywords

Photothermal therapy
Biofilm
Photodynamic therapy
Chemistry
Photochemistry
Nanotechnology
Materials science
Bacteria

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