Physical Double‐Network Hydrogel Adhesives with Rapid Shape Adaptability, Fast Self‐Healing, Antioxidant and NIR/pH Stimulus‐Responsiveness for Multidrug‐Resistant Bacterial Infection and Removable Wound Dressing

Abstract Developing physical double‐network (DN) removable hydrogel adhesives with both high healing efficiency and photothermal antibacterial activities to cope with multidrug‐resistant bacterial infection, wound closure, and wound healing remains an ongoing challenge. An injectable physical DN self‐healing hydrogel adhesive under physiological conditions is designed to treat multidrug‐resistant bacteria infection and full‐thickness skin incision/defect repair. The hydrogel adhesive consists of catechol–Fe 3+ coordination cross‐linked poly(glycerol sebacate)‐ co ‐poly(ethylene glycol)‐ g ‐catechol and quadruple hydrogen bonding cross‐linked ureido‐pyrimidinone modified gelatin. It possesses excellent…

• NN
  National Natural Science Foundation of China

  Awards: 51673155, 51631007, 51973172
• NS
  Natural Science Foundation of Shaanxi Province

  Awards: 2019TD‐020, 2018JM5026
• SK
  State Key Laboratory for Mechanical Behavior of Materials
• FR
  Fundamental Research Funds for the Central Universities