articleEBioMedicineApr 18, 2020GOLD OA

Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients

JLJing LiuSLSumeng LiJLJia LiuBLBoyun LiangXWXiaobei Wang

Union Hospital · Huazhong University of Science and Technology · +4 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

BackgroundThe dynamic changes of lymphocyte subsets and cytokines profiles of patients with novel coronavirus disease (COVID-19) and their correlation with the disease severity remain unclear.MethodsPeripheral blood samples were longitudinally collected from 40 confirmed COVID-19 patients and examined for lymphocyte subsets by flow cytometry and cytokine profiles by specific immunoassays.FindingsOf the 40 COVID-19 patients enrolled, 13 severe cases showed significant and sustained decreases in lymphocyte counts [0·6 (0·6-0·8)] but increases in neutrophil counts [4·7 (3·6-5·8)] than 27 mild cases [1.1 (0·8-1·4); 2·0 (1·5-2·9)]. Further analysis demonstrated significant decreases in the counts of T cells,…

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1,740
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40.38
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100%
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50

Topics & keywords

Topics
Keywords
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  • Immunology
  • Peripheral blood
  • Medicine
  • Coronavirus disease 2019 (COVID-19)
  • 2019-20 coronavirus outbreak
  • Peripheral
  • Cytokine
UN Sustainable Development Goals
  • Good health and well-being
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