Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
The University of Texas at Austin · National Institutes of Health · +1 more institution
Abstract
The outbreak of a novel coronavirus (2019-nCoV) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics. To facilitate medical countermeasure development, we determined a 3.5-angstrom-resolution cryo-electron microscopy structure of the 2019-nCoV S trimer in the prefusion conformation. The predominant state of the trimer has one of the three receptor-binding domains (RBDs) rotated up in a receptor-accessible conformation. We also provide biophysical and structural evidence that the 2019-nCoV S protein binds angiotensin-converting enzyme 2 (ACE2) with higher…
Citation impact
- FWCI
- 222.85
- Percentile
- 100%
- References
- 42
Authors
8- DWDaniel WrappCorresponding
The University of Texas at Austin
- NWNianshuang WangCorresponding
The University of Texas at Austin
- KSKizzmekia S. Corbett
National Institutes of Health, National Institute of Allergy and Infectious Diseases
- JAJory A. Goldsmith
The University of Texas at Austin
- CHChing‐Lin Hsieh
The University of Texas at Austin
Topics & keywords
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Coronavirus disease 2019 (COVID-19)
- Trimer
- Monoclonal antibody
- Coronavirus
- Antibody
- 2019-20 coronavirus outbreak
- Chemistry
- Good health and well-being