reviewMicroorganismsFeb 23, 2020GOLD OA

The Human Oral Microbiome in Health and Disease: From Sequences to Ecosystems

JRJesse R. WillisTGToni Gabaldón

Barcelona Supercomputing Center · Institute for Research in Biomedicine · +2 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

T: The human oral cavity is home to an abundant and diverse microbial community (i.e., the oral microbiome), whose composition and roles in health and disease have been the focus of intense research in recent years. Thanks to developments in sequencing-based approaches, such as 16S ribosomal RNA metabarcoding, whole metagenome shotgun sequencing, or meta-transcriptomics, we now can efficiently explore the diversity and roles of oral microbes, even if unculturable. Recent sequencing-based studies have charted oral ecosystems and how they change due to lifestyle or disease conditions. As studies progress, there is increasing evidence of an important role of the oral microbiome in diverse health conditions, which…

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469
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Topics & keywords

Topics
Keywords
  • Microbiome
  • Oral Microbiome
  • Metagenomics
  • Oral cavity
  • Biology
  • Computational biology
  • Human microbiome
  • Disease
UN Sustainable Development Goals
  • Life in Land
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