A cell atlas of human thymic development defines T cell repertoire formation

Thymus development, cell by cell The human thymus is the organ responsible for the maturation of many types of T cells, which are immune cells that protect us from infection. However, it is not well known how these cells develop with a full immune complement that contains the necessary variation to protect us from a variety of pathogens. By performing single-cell RNA sequencing on more than 250,000 cells, Park et al. examined the changes that occur in the thymus over the course of a human life. They found that development occurs in a coordinated manner among immune cells and with their developmental microenvironment. These data allowed for the creation of models of how T cells with different specific immune…

• EM
  European Molecular Biology Organization

  Award: ALT 490-2017
• WT
  Wellcome Trust

  Awards: WT206194, WT107931/Z/15/Z, WT211276/Z/18/Z
• FW
  Fonds Wetenschappelijk Onderzoek

  Award: G053816N
• MR
  Medical Research Council

  Awards: MC_PC_12009, MR/R006237/1, MR/R006237/1, MC_PC_17230
• ER
  European Research Council

  Award: 646794