reviewFrontiers in Cardiovascular MedicineFeb 25, 2020GOLD OA

Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease

ACAlan ChaitLJLaura J. den Hartigh

University of Washington

PubMed
Indexed incrossrefdoajpubmed

Abstract

Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date several types of adipose tissue have been identified, namely white, brown, and beige, that reside in various specific anatomical locations throughout the body. The cellular composition, secretome, and location of these adipose depots define their function in health and metabolic disease. In obesity, adipose tissue becomes dysfunctional, promoting a pro-inflammatory, hyperlipidemic and insulin resistant environment that contributes to type 2 diabetes mellitus (T2DM). Concurrently, similar features that result from adipose tissue dysfunction also promote cardiovascular disease (CVD) by mechanisms that can be augmented by…

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Topics & keywords

Topics
Keywords
  • Adipose tissue
  • Adipokine
  • Inflammation
  • Type 2 diabetes
  • White adipose tissue
  • Medicine
  • Endocrinology
  • Diabetes mellitus
UN Sustainable Development Goals
  • Good health and well-being
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