High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role in the entry of virus into the cell to cause the final infection. To investigate the potential route of 2019-nCov infection on the mucosa of oral cavity, bulk RNA-seq profiles from two public databases including The Cancer Genome Atlas (TCGA) and Functional Annotation of The Mammalian Genome Cap Analysis of Gene Expression (FANTOM5 CAGE) dataset were collected. RNA-seq profiling data of 13 organ types with para-carcinoma normal tissues from TCGA and 14 organ types with normal tissues from FANTOM5 CAGE were analyzed in order to explore and validate the expression of ACE2 on the mucosa of oral cavity. Further,…

• NN
  National Natural Science Foundation of China

  Awards: 81991502, B14038, 81771081, 81520108009, 81991500
• MO
  Ministry of Education, India
• HE
  Higher Education Discipline Innovation Project

  Award: B14038