Bioinspired Construction of a Nanozyme-Based H 2 O 2 Homeostasis Disruptor for Intensive Chemodynamic Therapy
University of Science and Technology of China · Chinese Academy of Sciences · +2 more institutions
Abstract
The insufficient intracellular H2O2 level in tumor cells is closely associated with the limited efficacy of chemodynamic therapy (CDT). Despite tremendous efforts, engineering CDT agents with a straightforward and secure H2O2 supplying ability remains a great challenge. Inspired by the balance of H2O2 generation and elimination in cancer cells, herein, a nanozyme-based H2O2 homeostasis disruptor is fabricated to elevate the intracellular H2O2 level through facilitating H2O2 production and restraining H2O2 elimination for enhanced CDT. In the formulation, the disruptor with superoxide dismutase-mimicking activity can convert O2•– to H2O2, promoting the production of H2O2. Simultaneously, the suppression of…
Citation impact
- FWCI
- 34.32
- Percentile
- 100%
- References
- 64
Authors
9- YSYanjuan Sang
University of Science and Technology of China, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- FCFangfang Cao
University of Science and Technology of China, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- WLWei Li
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences
- LZLu Zhang
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences
- YYYawen You
University of Science and Technology of China, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
Topics & keywords
- Chemistry
- Intracellular
- Homeostasis
- Catalase
- Superoxide dismutase
- Downregulation and upregulation
- Cancer cell
- Cell biology