The GenomeAsia 100K Project enables genetic discoveries across Asia
University of California, San Francisco · University of Virginia · +33 more institutions
Abstract
The underrepresentation of non-Europeans in human genetic studies so far has limited the diversity of individuals in genomic datasets and led to reduced medical relevance for a large proportion of the world's population. Population-specific reference genome datasets as well as genome-wide association studies in diverse populations are needed to address this issue. Here we describe the pilot phase of the GenomeAsia 100K Project. This includes a whole-genome sequencing reference dataset from 1,739 individuals of 219 population groups and 64 countries across Asia. We catalogue genetic variation, population structure, disease associations and founder effects. We also explore the use of this dataset in imputation,…
Citation impact
- FWCI
- 43.18
- Percentile
- 100%
- References
- 76
Authors
69- JDJeffrey D. WallCorresponding
University of California, San Francisco
- ESEric Stawiski
- ARAakrosh Ratan
University of Virginia
- HLHie Lim Kim
Nanyang Technological University, Singapore Centre for Environmental Life Sciences Engineering
- CKChanghoon Kim
Seoul National University Bundang Hospital, Macrogen (South Korea)
Topics & keywords
- Imputation (statistics)
- Genome-wide association study
- Evolutionary biology
- Population
- Genetic diversity
- 1000 Genomes Project
- Biology
- Genome