Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease
Wuhan University · Renmin Hospital of Wuhan University · +2 more institutions
Abstract
Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver disease worldwide and is strongly associated with the presence of oxidative stress. Disturbances in lipid metabolism lead to hepatic lipid accumulation, which affects different reactive oxygen species (ROS) generators, including mitochondria, endoplasmic reticulum, and NADPH oxidase. Mitochondrial function adapts to NAFLD mainly through the downregulation of the electron transport chain (ETC) and the preserved or enhanced capacity of mitochondrial fatty acid oxidation, which stimulates ROS overproduction within different ETC components upstream of cytochrome c oxidase. However, non-ETC sources of ROS, in particular, fatty…
Citation impact
- FWCI
- 88.42
- Percentile
- 100%
- References
- 363
Authors
5- ZCZe Chen
Wuhan University, Renmin Hospital of Wuhan University
- RTRuifeng Tian
Renmin Hospital of Wuhan University, Wuhan University
- ZSZhi‐Gang She
Wuhan University, Renmin Hospital of Wuhan University
- JCJingjing Cai
Central South University, Wuhan University, Third Xiangya Hospital, Renmin Hospital of Wuhan University
- HLHongliang LiCorresponding
Wuhan University, Renmin Hospital of Wuhan University
Topics & keywords
- Nonalcoholic fatty liver disease
- Oxidative stress
- Reactive oxygen species
- NADPH oxidase
- Endoplasmic reticulum
- Mitochondrion
- Mitochondrial ROS
- Lipid metabolism