Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants
Guangxi University · Huazhong Agricultural University · +1 more institution
Abstract
The recent pandemic of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has raised global health concerns. The viral 3-chymotrypsin-like cysteine protease (3CLpro) enzyme controls coronavirus replication and is essential for its life cycle. 3CLpro is a proven drug discovery target in the case of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). Recent studies revealed that the genome sequence of SARS-CoV-2 is very similar to that of SARS-CoV. Therefore, herein, we analysed the 3CLpro sequence, constructed its 3D homology model, and screened it against a medicinal plant library containing 32,297 potential anti-viral…
Citation impact
- FWCI
- 143.02
- Percentile
- 100%
- References
- 39
Authors
4Topics & keywords
- Coronavirus
- Drug discovery
- Virology
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Middle East respiratory syndrome coronavirus
- Cysteine protease
- Coronavirus disease 2019 (COVID-19)
- Viral replication