Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus
Semnan University of Medical Sciences · University of Hull · +5 more institutions
Abstract
Type 2 diabetes mellitus (T2DM) is the most prevalent metabolic disorder characterized by chronic hyperglycemia and an inadequate response to circulatory insulin by peripheral tissues resulting in insulin resistance. Insulin resistance has a complex pathophysiology, and it is contributed to by multiple factors including oxidative stress. Oxidative stress refers to an imbalance between free radical production and the antioxidant system leading to a reduction of peripheral insulin sensitivity and contributing to the development of T2DM via several molecular mechanisms. In this review, we present the molecular mechanisms by which the oxidative milieu contributes to the pathophysiology of insulin resistance and…
Citation impact
- FWCI
- 44.09
- Percentile
- 100%
- References
- 146
Authors
4- HYHabib YaribeygiCorresponding
Semnan University of Medical Sciences
- TSThozhukat Sathyapalan
University of Hull, Hull York Medical School
- SLStephen L. Atkin
Weill Cornell Medical College in Qatar
- ASAmirhossein SahebkarCorresponding
Mashhad University of Medical Sciences, Biotechnology Research Center, Niroo Research Institute
Topics & keywords
- Insulin resistance
- Oxidative stress
- Diabetes mellitus
- Pathophysiology
- Type 2 Diabetes Mellitus
- Medicine
- Insulin
- Internal medicine
- Good health and well-being