Identification of region-specific astrocyte subtypes at single cell resolution
VIB-KU Leuven Center for Brain & Disease Research · KU Leuven · +9 more institutions
Abstract
Astrocytes, a major cell type found throughout the central nervous system, have general roles in the modulation of synapse formation and synaptic transmission, blood-brain barrier formation, and regulation of blood flow, as well as metabolic support of other brain resident cells. Crucially, emerging evidence shows specific adaptations and astrocyte-encoded functions in regions, such as the spinal cord and cerebellum. To investigate the true extent of astrocyte molecular diversity across forebrain regions, we used single-cell RNA sequencing. Our analysis identifies five transcriptomically distinct astrocyte subtypes in adult mouse cortex and hippocampus. Validation of our data in situ reveals distinct spatial…
Citation impact
- FWCI
- 43.57
- Percentile
- 100%
- References
- 66
Authors
13- MYMykhailo Y. BatiukCorresponding
VIB-KU Leuven Center for Brain & Disease Research, KU Leuven
- AMAraks Martirosyan
VIB-KU Leuven Center for Brain & Disease Research, KU Leuven
- JWJérôme Wahis
VIB-KU Leuven Center for Brain & Disease Research, KU Leuven
- FDFilip de Vin
VIB-KU Leuven Center for Brain & Disease Research, KU Leuven
- CMCatherine Marneffe
VIB-KU Leuven Center for Brain & Disease Research, KU Leuven
Topics & keywords
- Astrocyte
- Forebrain
- Neuroscience
- Biology
- Cell type
- Hippocampus
- Central nervous system
- Cell