The Role of Inflammation in the Pathogenesis of Osteoarthritis
National University of Malaysia
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Abstract
A joint is the point of connection between two bones in our body. Inflammation of the joint leads to several diseases, including osteoarthritis, which is the concern of this review. Osteoarthritis is a common chronic debilitating joint disease mainly affecting the elderly. Several studies showed that inflammation triggered by factors like biomechanical stress is involved in the development of osteoarthritis. This stimulates the release of early-stage inflammatory cytokines like interleukin-1 beta (IL-1 β ), which in turn induces the activation of signaling pathways, such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF- κ B), phosphoinositide 3-kinase/protein kinase B (PI3K/AKT), and…
Citation impact
510
total citations
- FWCI
- 51.77
- Percentile
- 100%
- References
- 111
Citations per year
Authors
2Topics & keywords
Topics
Keywords
- Inflammation
- Osteoarthritis
- Pathogenesis
- Matrix metalloproteinase
- Kinase
- Medicine
- PI3K/AKT/mTOR pathway
- Protein kinase B
UN Sustainable Development Goals
- Good health and well-being
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