reviewInternational Journal of Molecular SciencesMar 6, 2020GOLD OA

The Diabetes Mellitus–Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation

AVAnastasia V. PoznyakAVAndrey V. GrechkoPPPaolo PoggioVAVeronika A. MyasoedovaVAValentina Alfieri

Institute for Atherosclerosis Research · V.A. Negovsky Scientific Research Institute of General Reanimatology · +3 more institutions

PubMed
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Abstract

Diabetes mellitus comprises a group of carbohydrate metabolism disorders that share a common main feature of chronic hyperglycemia that results from defects of insulin secretion, insulin action, or both. Insulin is an important anabolic hormone, and its deficiency leads to various metabolic abnormalities in proteins, lipids, and carbohydrates. Atherosclerosis develops as a result of a multistep process ultimately leading to cardiovascular disease associated with high morbidity and mortality. Alteration of lipid metabolism is a risk factor and characteristic feature of atherosclerosis. Possible links between the two chronic disorders depending on altered metabolic pathways have been investigated in numerous…

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1,137
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Topics & keywords

Topics
Keywords
  • Diabetes mellitus
  • Dyslipidemia
  • Medicine
  • Inflammation
  • Lipid metabolism
  • Internal medicine
  • Disease
  • Pathogenesis
UN Sustainable Development Goals
  • Good health and well-being
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