preprintmedRxivMar 3, 2020GREEN OA

Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019

JZJuanjuan ZhaoQYQuan YuanHWHaiyan WangWLWei LiuXLXuejiao Liao

Shenzhen Third People’s Hospital · Xiamen University · +1 more institution

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Abstract

Summary Background The novel coronavirus SARS-CoV-2 is a newly emerging virus. The antibody response in infected patient remains largely unknown, and the clinical values of antibody testing have not been fully demonstrated. Methods A total of 173 patients with confirmed SARS-CoV-2 infection were enrolled. Their serial plasma samples (n = 535) collected during the hospitalization period were tested for total antibodies (Ab), IgM and IgG against SARS-CoV-2 using immunoassays. The dynamics of antibodies with the progress and severity of disease was analyzed. Results Among 173 patients, the seroconversion rate for Ab, IgM and IgG was 93.1% (161/173), 82.7% (143/173) and 64.7% (112/173), respectively. Twelve…

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508
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12
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Authors

24

Topics & keywords

Topics
Keywords
  • Seroconversion
  • Antibody
  • Medicine
  • Immunology
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  • Coronavirus disease 2019 (COVID-19)
  • Immunoglobulin M
  • Internal medicine
UN Sustainable Development Goals
  • Good health and well-being
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