reviewAngewandte Chemie International EditionMar 5, 2020Closed access

Activatable Molecular Probes for Second Near‐Infrared Fluorescence, Chemiluminescence, and Photoacoustic Imaging

JHJiaguo HuangKPKanyi Pu

Nanyang Technological University

PubMed
Indexed incrossrefpubmed

Abstract

Optical imaging plays a crucial role in biomedicine. However, due to strong light scattering and autofluorescence in biological tissue between 650-900 nm, conventional optical imaging often has a poor signal-to-background ratio and shallow penetration depth, which limits its ability in deep-tissue in vivo imaging. Second near-infrared fluorescence, chemiluminescence, and photoacoustic imaging modalities mitigate these issues by their respective advantages of minimized light scattering, eliminated external excitation, and ultrasound detection. To enable disease detection, activatable molecular probes (AMPs) with the ability to change their second near-infrared fluorescence, chemiluminescence, or photoacoustic…

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Authors

2

Topics & keywords

Topics
Keywords
  • Molecular imaging
  • Autofluorescence
  • Photoacoustic imaging in biomedicine
  • Chemiluminescence
  • Fluorescence-lifetime imaging microscopy
  • Fluorescence
  • Materials science
  • Preclinical imaging
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