Role of p53 in the Regulation of Cellular Senescence
University of Siena · Temple University · +1 more institution
Abstract
The p53 transcription factor plays a critical role in cellular responses to stress. Its activation in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs cellular senescence or apoptosis, thereby maintaining genome integrity. Senescence is a permanent cell-cycle arrest that has a crucial role in aging, and it also represents a robust physiological antitumor response, which counteracts oncogenic insults. In addition, senescent cells can also negatively impact the surrounding tissue microenvironment and the neighboring cells by secreting pro-inflammatory cytokines, ultimately triggering tissue dysfunction and/or unfavorable outcomes. This review focuses on the characteristics…
Citation impact
- FWCI
- 33.71
- Percentile
- 100%
- References
- 132
Authors
5Topics & keywords
- Senescence
- Cell biology
- DNA damage
- Biology
- Transcription factor
- Cellular senescence
- Cell cycle checkpoint
- Cell cycle