PGC-1 α , Inflammation, and Oxidative Stress: An Integrative View in Metabolism
Universitat de València · Leitat Technological Center
Abstract
Peroxisome proliferator-activated receptor- γ coactivator (PGC)-1 α is a transcriptional coactivator described as a master regulator of mitochondrial biogenesis and function, including oxidative phosphorylation and reactive oxygen species detoxification. PGC-1 α is highly expressed in tissues with high energy demands, and it is clearly associated with the pathogenesis of metabolic syndrome and its principal complications including obesity, type 2 diabetes mellitus, cardiovascular disease, and hepatic steatosis. We herein review the molecular pathways regulated by PGC-1 α , which connect oxidative stress and mitochondrial metabolism with inflammatory response and metabolic syndrome. PGC-1 α regulates the…
Citation impact
- FWCI
- 39.57
- Percentile
- 100%
- References
- 237
Authors
5Topics & keywords
- Oxidative stress
- Thioredoxin
- Biology
- Reactive oxygen species
- Coactivator
- Mitochondrial biogenesis
- Mitochondrion
- Superoxide dismutase
- Good health and well-being