Targeting Oxidative Stress and Inflammation to Prevent Ischemia-Reperfusion Injury

The cerebral ischemia injury can result in neuronal death and/or functional impairment, which leads to further damage and dysfunction after recovery of blood supply. Cerebral ischemia/reperfusion injury (CIRI) often causes irreversible brain damage and neuronal injury and death, which involves many complex pathological processes including oxidative stress, amino acid toxicity, the release of endogenous substances, inflammation and apoptosis. Oxidative stress and inflammation are interactive and play critical roles in ischemia/reperfusion injury in the brain. Oxidative stress is important in the pathological process of ischemic stroke and is critical for the cascade development of ischemic injury. Oxidative…

• NN
  National Natural Science Foundation of China

  Awards: 81301019, 81870939, 81571147, 81771283, 81571147, 81870939, 81771283, 81301019, 81571147, 81870939