reviewFrontiers in PharmacologyMar 20, 2020GOLD OA

The Drug-Resistance Mechanisms of Five Platinum-Based Antitumor Agents

JZJiabei ZhouYKYu KangLCLu ChenHWHua WangJLJunqing Liu

Zhejiang University · Zhejiang Cancer Hospital · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Platinum-based anticancer drugs, including cisplatin, carboplatin, oxaliplatin, nedaplatin, and lobaplatin, are heavily applied in chemotherapy regimens. However, the intrinsic or acquired resistance severely limit the clinical application of platinum-based treatment. The underlying mechanisms are incredibly complicated. Multiple transporters participate in the active transport of platinum-based antitumor agents, and the altered expression level, localization, or activity may severely decrease the cellular platinum accumulation. Detoxification components, which are commonly increasing in resistant tumor cells, can efficiently bind to platinum agents and prevent the formation of platinum-DNA adducts, but the…

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473
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100%
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Authors

7

Topics & keywords

Topics
Keywords
  • Nedaplatin
  • Carboplatin
  • Cisplatin
  • Oxaliplatin
  • Platinum
  • Cytotoxicity
  • Drug resistance
  • Pharmacology
UN Sustainable Development Goals
  • Good health and well-being
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