mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges

Mammalian target of rapamycin (mTOR) regulates cell proliferation, autophagy, and apoptosis by participating in multiple signaling pathways in the body. Studies have shown that the mTOR signaling pathway is also associated with cancer, arthritis, insulin resistance, osteoporosis, and other diseases. The mTOR signaling pathway, which is often activated in tumors, not only regulates gene transcription and protein synthesis to regulate cell proliferation and immune cell differentiation but also plays an important role in tumor metabolism. Therefore, the mTOR signaling pathway is a hot target in anti-tumor therapy research. In recent years, a variety of newly discovered mTOR inhibitors have entered clinical…

• NN
  National Natural Science Foundation of China

  Awards: 2015A050502048, 81541153
• GS
  Guangdong Science and Technology Department

  Awards: 2016B030309002, 2016A050503046, 2016A050503046, 2015A050502048 and 2016B030309002, 2015A050502048
• UO
  University of California, San Diego