SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
Broad Institute · Harvard University · +27 more institutions
Abstract
There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-CoV-2 spike (S) protein binds angiotensin-converting enzyme 2 (ACE2), and in concert with host proteases, principally transmembrane serine protease 2 (TMPRSS2), promotes cellular entry. The cell subsets targeted by SARS-CoV-2 in host tissues and the factors that regulate ACE2 expression remain unknown. Here, we leverage human, non-human primate, and mouse single-cell RNA-sequencing (scRNA-seq) datasets across health and disease to uncover putative targets of SARS-CoV-2 among tissue-resident cell subsets. We identify ACE2 and TMPRSS2…
Citation impact
- FWCI
- 55.64
- Percentile
- 100%
- References
- 179
Authors
121- CGCarly G.K. Ziegler
Broad Institute, Harvard University, Ragon Institute of MGH, MIT and Harvard, Massachusetts Institute of Technology
- SJSamuel J. Allon
Broad Institute, Ragon Institute of MGH, MIT and Harvard, Massachusetts Institute of Technology
- SKSarah K. Nyquist
Broad Institute, Ragon Institute of MGH, MIT and Harvard, Massachusetts Institute of Technology
- IMIan Mbano
Africa Health Research Institute, University of KwaZulu-Natal
- VNVincent N. Miao
Broad Institute, Harvard University, Ragon Institute of MGH, MIT and Harvard, Massachusetts Institute of Technology
Topics & keywords
- Biology
- TMPRSS2
- Proteases
- Interferon
- Immunology
- Furin
- Virology
- Interferon-stimulated gene
- Good health and well-being