The genetic architecture of the human cerebral cortex

Grasby, Katrina L.; Jahanshad, Neda; Painter, Jodie N.; Colodro‐Conde, Lucía; Bralten, Janita; Hibar, Derrek P.; Lind, Penelope A.; Pizzagalli, Fabrizio; Ching, Christopher R. K.; McMahon, Mary; Shatokhina, Natalia; Zsembik, Leo; Thomopoulos, Sophia I.; Zhu, Alyssa H.; Strike, Lachlan T.; Agartz, Ingrid; Alhusaini, Saud; Almeida, Marcio; Alnæs, Dag; Amlien, Inge K.; Andersson, Micael; Ard, Tyler; Armstrong, Nicola J.; Ashley‐Koch, Allison E.; Atkins, Joshua; Bernard, Manon; Brouwer, Rachel M.; Buimer, Elizabeth E.L.; Bülow, Robin; Bürger, Christian; Cannon, Dara M.; Chakravarty, M. Mallar; Chen, Qiang; Cheung, J.; Couvy‐Duchesne, Baptiste; Dale, Anders M.; Dalvie, Shareefa; Araujo, Tânia Kawasaki de; Zubicaray, Greig I. de; Zwarte, Sonja M. C. de; Braber, Anouk den; Doan, Nhat Trung; Dohm, Katharina; Ehrlich, Stefan; Engelbrecht, Hannah-Ruth; Erk, Susanne; Fan, Chun Chieh; Fedko, Iryna O.; Foley, Sonya; Ford, Judith M.; Fukunaga, Masaki; Garrett, Melanie E.; Ge, Tian; Giddaluru, Sudheer; Goldman, Aaron L.; Green, Melissa J.; Groenewold, Nynke A.; Grotegerd, Dominik; Gurholt, Tiril P.; Gutman, Boris A.; Hansell, Narelle K.; Harris, Mathew A.; Harrison, Marc; Haswell, Courtney C.; Hauser, Michael A.; Herms, Stefan; Heslenfeld, Dirk J.; Ho, New Fei; Hoehn, David; Hoffmann, Per; Holleran, Laurena; Hoogman, Martine; Hottenga, Jouke‐Jan; Ikeda, Masashi; Janowitz, Deborah; Jansen, Iris E.; Jia, Tianye; Jockwitz, Christiane; Kanai, Ryota; Karama, Sherif; Kasperavičiūtė, Dalia; Kaufmann, Tobias; Kelly, Sinéad; Kikuchi, Masataka; Klein, Marieke; Knapp, Michael; Knodt, Annchen R.; Krämer, Bernd; Lam, Max; Lancaster, T.; Lee, Phil H.; Lett, Tristram A.; Lewis, Lindsay B.; Lopes‐Cendes, Íscia; Luciano, Michelle; Macciardi, Fabìo; Marquand, André F.; Mathias, Samuel R.; Melzer, Tracy R.; Milaneschi, Yuri; Mirza‐Schreiber, Nazanin; Moreira, José C.V.; Mühleisen, Thomas W.; Müller‐Myhsok, Bertram; Najt, Pablo; Nakahara, Soichiro; Nho, Kwangsik; Loohuis, Loes M. Olde; Orfanos, Dimitri Papadopoulos; Pearson, John F.; Pitcher, Toni L.; Pütz, Benno; Quidé, Yann; Ragothaman, Anjanibhargavi; Rashid, Faisal; Reay, William R.; Redlich, Ronny; Reinbold, Céline S.; Repple, Jonathan; Richard, Geneviève; Riedel, Brandalyn C.; Risacher, Shannon L.; Rocha, Cristiane S.; Mota, Nina Roth; Salminen, Lauren E.; Saremi, Arvin; Saykin, Andrew J.; Schlag, Fenja; Schmaal, Lianne; Schofield, Peter R.; Secolin, Rodrigo; Shapland, Chin Yang; Shen, Li; Shin, Jean; Shumskaya, Elena; Sønderby, Ida E.; Sprooten, Emma; Tansey, Katherine E.; Teumer, Alexander; Thalamuthu, Anbupalam; Tordesillas‐Gutiérrez, Diana; Turner, Jessica A.; Uhlmann, Anne; Vallerga, Costanza L.; Meer, Dennis van der; Donkelaar, Marjolein M. J. van; Eijk, Liza van; Erp, Theo G.M. van; Haren, Neeltje E.M. van; Rooij, Daan van; Tol, Marie‐José van; Veldink, Jan H.; Verhoef, Ellen; Walton, Esther; Wang, Mingyuan; Wang, Yunpeng; Wardlaw, Joanna M.; Wen, Wei; Westlye, Lars T.; Whelan, Christopher D.; Witt, Stephanie H.; Wittfeld, Katharina; Wolf, Christiane; Wolfers, Thomas; Wu, Jing; Yasuda, Clarissa Lin; Zaremba, Dario; Zhang, Zuo; Zwiers, Marcel P.; Artiges, Éric; Assareh, Amelia A.; Ayesa‐Arriola, Rosa; Belger, Ayşenil; Brandt, Christine L.; Brown, Gregory G.; Cichon, Sven; Curran, Joanne E.; Davies, Gareth E.; Degenhardt, Franziska; Dennis, Michelle F.; Dietsche, Bruno; Djurovic, Srdjan; Doherty, Colin P.; Espiritu, Ryan; Garijo, Daniel; Gil, Yolanda; Gowland, Penny; Green, Robert C.; Häusler, Alexander N.; Heindel, Walter; Ho, Beng‐Choon; Hoffmann, Wolfgang; Holsboer, Florian; Homuth, Georg; Hosten, Norbert; Jack, Clifford R.; Jang, MiHyun; Jansen, Andreas; Kimbrel, Nathan A.; Kolskår, Knut K.; Koops, Sanne; Krug, Axel; Lim, Kelvin O.; Luykx, Jurjen J.; Mathalon, Daniel H.; Mather, Karen A.; Mattay, Venkata S.; Matthews, Sarah; Son, Jacqueline Mayoral-van; McEwen, Sarah; Melle, Ingrid; Morris, Derek W.; Mueller, Bryon A.; Nauck, Matthias; Nordvik, Jan Egil; Nöthen, Markus M.; OʼLeary, Daniel S.; Opel, Nils; Martinot, Marie‐Laure Paillère; Pike, G. Bruce; Preda, Adrian; Quinlan, Erin Burke; Rasser, Paul E.; Ratnakar, Varun; Reppermund, Simone; Steen, Vidar M.; Tooney, Paul A.; Torres, Fábio R.; Veltman, Dick J.; Voyvodic, James; Whelan, Robert; White, Tonya; Yamamori, Hidenaga; Adams, Hieab H.H.; Bis, Joshua C.; Debette, Stéphanie; DeCarli, Charles; Fornage, Myriam; Guðnason, Vilmundur; Hofer, Edith; Ikram, M. Arfan; Launer, Lenore J.; Longstreth, W.T.; López, Oscar L.; Mazoyer, Bernard; Mosley, Thomas H.; Roshchupkin, Gennady V.; Satizábal, Claudia L.; Schmidt, Reinhold; Seshadri, Sudha; Yang, Qiong; Initiative¶, Alzheimer’s Disease Neuroimaging; Initiative¶, Parkinson’s Progression Markers; Alvim, Marina K. M.; Ames, David; Anderson, Tim; Andreassen, Ole A.; Vásquez, Alejandro Arias; Bastin, Mark E.; Baune, Bernhard T.; Beckham, Jean C.; Blangero, John; Boomsma, Dorret I.; Brodaty, Henry; Brunner, Han G.; Buckner, Randy L.; Buitelaar, Jan K.; Bustillo, Juan; Cahn, Wiepke; Cairns, Murray J.; Calhoun, Vince D.; Carr, Vaughan J.; Caseras, Xavier; Caspers, Svenja; Cavalleri, Gianpiero L.; Cendes, Fernando; Corvin, Aiden; Crespo‐Facorro, Benedicto; Dalrymple‐Alford, John C.; Dannlowski, Udo; Geus, Eco J. C. de; Deary, Ian J.; Delanty, Norman; Depondt, Chantal; Desrivières, Sylvane; Donohoe, Gary; Espeseth, Thomas; Fernández, Guillén; Fisher, Simon E.; Flor, Herta; Forstner, Andreas J.; Francks, Clyde; Franke, Barbara; Glahn, David C.; Gollub, Randy L.; Grabe, Hans J.; Gruber, Oliver; Håberg, Asta K.; Hariri, Ahmad R.; Hartman, Catharina A.; Hashimoto, Ryota; Heinz, Andreas; Henskens, Frans; Hillegers, Manon H. J.; Hoekstra, Pieter J.; Holmes, Avram J.; Hong, L. Elliot; Hopkins, William D.; Pol, Hilleke E. Hulshoff; Jernigan, Terry L.; Jönsson, Erik G.; Kahn, René S.; Kennedy, Martin A.; Kircher, Tilo; Kochunov, Peter; Kwok, John B.; Hellard, Stéphanie Le; Loughland, Carmel M.; Martin, Nicholas G.; Martinot, Jean‐Luc; McDonald, Colm; McMahon, Katie L.; Meyer‐Lindenberg, Andreas; Michie, Patricia T.; Morey, Rajendra A.; Mowry, Bryan; Nyberg, Lars; Oosterlaan, Jaap; Ophoff, Roel A.; Pantelis, Christos; Paus, Tomáš; Pausová, Zdenka; Penninx, Brenda W.J.H.; Polderman, Tinca J. C.; Posthuma, Daniëlle; Rietschel, Marcella; Roffman, Joshua L.; Rowland, Laura M.; Sachdev, Perminder S.; Sämann, Philipp G.; Schall, Ulrich; Schumann, Günter; Scott, Rodney J.; Sim, Kang; Sisodiya, Sanjay M.; Smoller, Jordan W.; Sommer, Iris E.; Pourcain, Beaté St; Stein, Dan J.; Toga, Arthur W.; Trollor, Julian N.; Wee, Nic J.A. van der; Ent, Dennis van ‘t; Völzke, Henry; Walter, Henrik; Weber, Bernd; Weinberger, Daniel R.; Wright, Margaret J.; Zhou, Juan; Stein, Jason L.; Thompson, Paul M.; Medland, Sarah E.

doi:10.1126/science.aay6690

reviewScienceMar 19, 2020GREEN OA

The genetic architecture of the human cerebral cortex

KLKatrina L. Grasby NJNeda Jahanshad JNJodie N. Painter LCLucía Colodro‐Conde JBJanita Bralten

QIMR Berghofer Medical Research Institute · University of Southern California · +220 more institutions

PubMed

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Abstract

INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with human cortical structure at both global and regional levels, we conducted a genome-wide association meta-analysis of brain MRI data from 51,665 individuals across 60 cohorts. We analyzed the surface area and average…

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Topics

Keywords

Neuroscience
Cerebral cortex
Biology
Cortex (anatomy)
Functional magnetic resonance imaging
Human brain
Genetic architecture
Gene

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Good health and well-being

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