Insights into human genetic variation and population history from 929 diverse genomes
The Francis Crick Institute · Wellcome Sanger Institute · +9 more institutions
Abstract
Genome sequences from diverse human groups are needed to understand the structure of genetic variation in our species and the history of, and relationships between, different populations. We present 929 high-coverage genome sequences from 54 diverse human populations, 26 of which are physically phased using linked-read sequencing. Analyses of these genomes reveal an excess of previously undocumented common genetic variation private to southern Africa, central Africa, Oceania, and the Americas, but an absence of such variants fixed between major geographical regions. We also find deep and gradual population separations within Africa, contrasting population size histories between hunter-gatherer and…
Citation impact
- FWCI
- 98.66
- Percentile
- 100%
- References
- 79
Authors
21- ABAnders BergströmCorresponding
The Francis Crick Institute, Wellcome Sanger Institute
- SMShane McCarthyCorresponding
University of Cambridge, Wellcome Sanger Institute
- RHRuoyun HuiCorresponding
University of Cambridge
- MAMohamed A. AlmarriCorresponding
Wellcome Sanger Institute
- QAQasim Ayub
Monash University Malaysia, Wellcome Sanger Institute
Topics & keywords
- Variation (astronomy)
- Genetic variation
- Evolutionary biology
- Genome
- Human genetic variation
- Population
- Biology
- Human genome
Funding
- WTWellcome TrustAwards: 207492, 852558, FC001595, 206194, 217223/Z/19/Z, 098051
- FCFrancis Crick InstituteAwards: 852558, 217223/Z/19/Z, FC001595
- CRCancer Research UKAwards: 217223/Z/19/Z, FC001595, 852558
- ETEesti TeadusagentuurAward: PUT1036
- GCGates Cambridge Trust
- MRMedical Research CouncilAwards: 217223/Z/19/Z, FC001595, 098051, 852558