Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
Université Paris Cité · Cornell University · +69 more institutions
Abstract
Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.
Citation impact
- FWCI
- 52.55
- Percentile
- 100%
- References
- 351
Authors
54- LGLorenzo GalluzziCorresponding
Université Paris Cité, Cornell University, Lander Institute, Yale University
- IVIlio Vitale
Italian institute for Genomic Medicine, Candiolo Cancer Institute, Istituti di Ricovero e Cura a Carattere Scientifico
- SHSarah H. Warren
Nanostring Technologies (United States)
- SASandy Adjemian
Ghent University, VIB-UGent Center for Inflammation Research
- PAPatrizia Agostinis
VIB-KU Leuven Center for Cancer Biology, KU Leuven
Topics & keywords
- Acquired immune system
- Immune system
- Programmed cell death
- Immunogenic cell death
- Antigenicity
- Immunology
- Medicine
- Computer science
- Good health and well-being