PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson’s disease
Harvard University · Johns Hopkins University · +6 more institutions
Abstract
That certain cell types in the central nervous system are more likely to undergo neurodegeneration in Parkinson's disease is a widely appreciated but poorly understood phenomenon. Many vulnerable subpopulations, including dopamine neurons in the substantia nigra pars compacta, have a shared phenotype of large, widely distributed axonal networks, dense synaptic connections, and high basal levels of neural activity. These features come at substantial bioenergetic cost, suggesting that these neurons experience a high degree of mitochondrial stress. In such a context, mechanisms of mitochondrial quality control play an especially important role in maintaining neuronal survival. In this review, we focus on…
Citation impact
- FWCI
- 23.22
- Percentile
- 100%
- References
- 204
Authors
3- PGPreston GeCorresponding
Harvard University, Johns Hopkins University, Johns Hopkins Medicine, Institute of Cognitive and Brain Sciences, Orthopaedic Research Foundation, Massachusetts Institute of Technology
- VLValina L. Dawson
Johns Hopkins University, Johns Hopkins Medicine, Helicon Foundation, Medical Research Foundation
- TMTed M. Dawson
Johns Hopkins University, Johns Hopkins Medicine, Helicon Foundation, Medical Research Foundation
Topics & keywords
- Parkin
- PINK1
- Neurodegeneration
- Neuroscience
- Pars compacta
- Substantia nigra
- Parkinson's disease
- Biology
Funding
- AHAdrienne Helis Malvin Medical Research FoundationAward: M-2014
- JFJPB Foundation
- DHDiana Helis Henry Medical Research Foundation
- NINational Institute on AgingAward: AG059686
- NINational Institute of General Medical SciencesAward: T32GM007753
- NINational Institute of Neurological Disorders and StrokeAwards: NS097049, NS38377