Update on Fundamental Mechanisms of Thyroid Cancer

The incidence of thyroid cancer (TC) has increased worldwide over the past four decades. TC is divided into three main histological types: differentiated (papillary and follicular TC), undifferentiated (poorly differentiated and anaplastic TC), and medullary TC, arising from thyroid C cells. This review discusses the molecular mechanisms associated to the pathogenesis of different types of TC and their clinical relevance. In the last years, progresses in the genetic characterization of TC have provided molecular markers for diagnosis, risk stratification and treatment targets. Recently, papillary thyroid cancer has been reclassified into two molecular subtypes, named BRAF-like and RAS-like, associated to…

• UD
  Università degli Studi di Salerno
• UD
  Università degli Studi di Perugia