Ultrafine Titanium Monoxide (TiO 1+ x ) Nanorods for Enhanced Sonodynamic Therapy

Ultrasound (US)-triggered sonodynamic therapy (SDT) that enables noninvasive treatment of large internal tumors has attracted widespread interest. For improvement in the therapeutic responses to SDT, more effective and stable sonosensitizers are still required. Herein, ultrafine titanium monoxide nanorods (TiO1+x NRs) with greatly improved sono-sensitization and Fenton-like catalytic activity were fabricated and used for enhanced SDT. TiO1+x NRs with an ultrafine rodlike structure were successfully prepared and then modified with polyethylene glycol (PEG). Compared to the conventional sonosensitizer, TiO2 nanoparticles, the PEG–TiO1+x NRs resulted in much more efficient US-induced generation of reactive oxygen…

• NN
  National Natural Science Foundation of China

  Awards: 51525203, 51572180, 51761145041
• MO
  Ministry of Science and Technology of the People's Republic of China

  Award: 2016YFA0201200
• GO
  Government of Jiangsu Province

  Award: 2019 SJKY19_2282
• NS
  Natural Science Foundation of Jiangsu Province

  Award: BK20170063
• SU
  Soochow University
• PA
  Priority Academic Program Development of Jiangsu Higher Education Institutions
• CI
  Collaborative Innovation Center of Suzhou Nano Science and Technology