Targeted sequencing in DLBCL, molecular subtypes, and outcomes: a Haematological Malignancy Research Network report
University of York · St James's University Hospital · +6 more institutions
Abstract
Based on the profile of genetic alterations occurring in tumor samples from selected diffuse large B-cell lymphoma (DLBCL) patients, 2 recent whole-exome sequencing studies proposed partially overlapping classification systems. Using clustering techniques applied to targeted sequencing data derived from a large unselected population-based patient cohort with full clinical follow-up (n = 928), we investigated whether molecular subtypes can be robustly identified using methods potentially applicable in routine clinical practice. DNA extracted from DLBCL tumors diagnosed in patients residing in a catchment population of ∼4 million (14 centers) were sequenced with a targeted 293-gene hematological-malignancy…
Citation impact
- FWCI
- 38.58
- Percentile
- 100%
- References
- 34
Authors
17Topics & keywords
- Diffuse large B-cell lymphoma
- Oncology
- Population
- Internal medicine
- Biology
- Malignancy
- Exome sequencing
- Vincristine
- No poverty