articlePLoS MedicineMar 23, 2020GOLD OA

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis

TGTom G. RichardsonESEleanor SandersonTPTom PalmerMAMika Ala‐KorpelaBABrian A. Ference

University of Bristol · Medical Research Council · +7 more institutions

PubMed
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Abstract

BACKGROUND: Circulating lipoprotein lipids cause coronary heart disease (CHD). However, the precise way in which one or more lipoprotein lipid-related entities account for this relationship remains unclear. Using genetic instruments for lipoprotein lipid traits implemented through multivariable Mendelian randomisation (MR), we sought to compare their causal roles in the aetiology of CHD. METHODS AND FINDINGS: We conducted a genome-wide association study (GWAS) of circulating non-fasted lipoprotein lipid traits in the UK Biobank (UKBB) for low-density lipoprotein (LDL) cholesterol, triglycerides, and apolipoprotein B to identify lipid-associated single nucleotide polymorphisms (SNPs). Using data from…

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Topics & keywords

Topics
Keywords
  • Genome-wide association study
  • Apolipoprotein B
  • Internal medicine
  • Lipoprotein
  • Mendelian randomization
  • Cholesterol
  • Single-nucleotide polymorphism
  • Medicine
UN Sustainable Development Goals
  • Good health and well-being
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