Antifouling Strategies for Selective In Vitro and In Vivo Sensing
University of Oxford · Qingdao University of Science and Technology · +1 more institution
Abstract
The ability to fabricate sensory systems capable of highly selective operation in complex fluid will undoubtedly underpin key future developments in healthcare. However, the abundance of (bio)molecules in these samples can significantly impede performance at the transducing interface where nonspecific adsorption (fouling) can both block specific signal (reducing sensitivity) and greatly reduce assay specificity. Herein, we aim to provide a comprehensive review discussing concepts and recent advances in the construction of antifouling sensors that are, through the use of chemical, physical, or biological engineering, capable of operating in complex sample matrix (e.g., serum). We specifically highlight a range…
Citation impact
- FWCI
- 47.23
- Percentile
- 100%
- References
- 314
Authors
6Topics & keywords
- Chemistry
- Nanotechnology
- Biosensor
- Nucleic acid
- Biofouling
- Complex matrix
- Analyte
- Interface (matter)