reviewBiomedicine & PharmacotherapyMar 28, 2020GOLD OA

The emerging role of ferroptosis in inflammation

YSYitian SunPCPeng ChenBZBingtao ZhaiMZMingming ZhangXYXiang Yu

Hangzhou Normal University · Affiliated Hospital of Hangzhou Normal University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Ferroptosis is a newly discovered type of cell death triggered by intracellular phospholipid peroxidation that is morphologically, biologically and genetically distinct from other types of cell death. Ferroptosis is classified as regulated necrosis and is more immunogenic than apoptosis. To date, compelling evidence indicates that ferroptosis plays an important role in inflammation, and several antioxidants functioning as ferroptosis inhibitors have been shown to exert anti-inflammatory effects in experimental models of certain diseases. Our review provides an overview of the link between ferroptosis and inflammation; a better understanding of the mechanisms underlying ferroptosis and inflammation may hasten…

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736
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FWCI
48.30
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100%
References
157
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Authors

11

Topics & keywords

Topics
Keywords
  • Inflammation
  • Programmed cell death
  • Apoptosis
  • GPX4
  • Intracellular
  • Biology
  • Necrosis
  • Immunology
UN Sustainable Development Goals
  • Good health and well-being
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