Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients
Wuhan University · Zhongnan Hospital of Wuhan University · +4 more institutions
Abstract
Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. To characterize the transcriptional signatures of host inflammatory response to SARS-CoV-2 (HCoV-19) infection, we carried out transcriptome sequencing of the RNAs isolated from the bronchoalveolar lavage fluid (BALF) and peripheral blood mononuclear cells (PBMC) specimens of COVID-19 patients. Our results reveal distinct host inflammatory cytokine profiles to SARS-CoV-2…
Citation impact
- FWCI
- 27.77
- Percentile
- 100%
- References
- 53
Authors
19- YXYong Xiong
Wuhan University, Zhongnan Hospital of Wuhan University
- YLYuan Liu
Wuhan University, State Key Laboratory of Virology
- LCLiu Cao
Sun Yat-sen University, Institute of Infection and Immunity
- DWDehe Wang
Wuhan University, State Key Laboratory of Virology
- MGMing Guo
Wuhan University, State Key Laboratory of Virology
Topics & keywords
- Bronchoalveolar lavage
- Peripheral blood mononuclear cell
- Transcriptome
- Immunology
- Immune system
- Chemokine
- CXCL10
- Medicine
- Good health and well-being