3D Extracellular Matrix Mimics: Fundamental Concepts and Role of Materials Chemistry to Influence Stem Cell Fate
Centre National de la Recherche Scientifique · Université Paris-Saclay · +2 more institutions
Abstract
Cell microenvironments. This requires fine-tuning the biochemical and structural actors in synthetic ECMs. This review will present the fundamentals of the ECM, cover the chemical and structural features of the scaffolds used to generate ECM mimics, discuss the nature of the signaling biomolecules required and exploited to generate bioresponsive cell microenvironments able to induce a specific cell fate, and highlight the synthetic strategies involved in creating functional 3D ECM mimics.
Citation impact
- FWCI
- 25.08
- Percentile
- 100%
- References
- 402
Authors
6- JNJulien NicolasCorresponding
Centre National de la Recherche Scientifique, Université Paris-Saclay, Institut Galien Paris-Saclay
- SMSofia Magli
University of Milano-Bicocca
- LRLinda Rabbachin
University of Milano-Bicocca
- SSSusanna Sampaolesi
University of Milano-Bicocca
- FNFrancesco Nicotra
University of Milano-Bicocca
Topics & keywords
- Extracellular matrix
- Regenerative medicine
- Chemistry
- Biomolecule
- Cell fate determination
- Chemical biology
- Drug discovery
- Biophysics