Neutralizing antibody responses to SARS-CoV-2 in a COVID-19 recovered patient cohort and their implications
Shanghai Public Health Clinical Center
Abstract
Background The COVID-19 pandemic caused by SARS-CoV-2 coronavirus threatens global public health. Currently, neutralizing antibodies (NAbs) versus this virus are expected to correlate with recovery and protection of this disease. However, the characteristics of these antibodies have not been well studied in association with the clinical manifestations in patients. Methods Plasma collected from 175 COVID-19 recovered patients with mild symptoms were screened using a safe and sensitive pseudotyped-lentiviral-vector-based neutralization assay. Spike-binding antibody in plasma were determined by ELISA using RBD, S1, and S2 proteins of SARS-CoV-2. The levels and the time course of SARS-CoV-2-specific NAbs and the…
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Authors
14Topics & keywords
- Antibody
- Titer
- Virology
- Medicine
- Neutralizing antibody
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Neutralization
- Coronavirus disease 2019 (COVID-19)
- Good health and well-being