reviewCellsApr 3, 2020GOLD OA

Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives

NRNatascha RoehlenÉCÉmilie CrouchetTFThomas F. Baumert

Institute for Translational Medicine and Liver Disease · Université de Strasbourg · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global health. Correlating with liver disease progression, fibrosis is a key factor for liver disease outcome and risk of hepatocellular carcinoma (HCC). Despite different mechanism of primary liver injury and disease-specific cell responses, the progression of fibrotic liver disease follows shared patterns across the main liver disease etiologies. Scientific discoveries within the last decade have transformed the understanding of the mechanisms of liver fibrosis. Removal or elimination of the causative agent such as control or cure of viral infection has shown that liver fibrosis is reversible. However, reversal often…

Citation impact

1,170
total citations
FWCI
65.08
Percentile
100%
References
415
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Authors

3

Topics & keywords

Topics
Keywords
  • Medicine
  • Fibrosis
  • Hepatocellular carcinoma
  • Liver disease
  • Disease
  • Chronic liver disease
  • Viral hepatitis
  • Liver fibrosis
UN Sustainable Development Goals
  • Good health and well-being
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