Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents

Objective Patients with renal failure suffer from symptoms caused by uraemic toxins, possibly of gut microbial origin, as deduced from studies in animals. The aim of the study is to characterise relationships between the intestinal microbiome composition, uraemic toxins and renal failure symptoms in human end-stage renal disease (ESRD). Design Characterisation of gut microbiome, serum and faecal metabolome and human phenotypes in a cohort of 223 patients with ESRD and 69 healthy controls. Multidimensional data integration to reveal links between these datasets and the use of chronic kidney disease (CKD) rodent models to test the effects of intestinal microbiome on toxin accumulation and disease severity.…

• AN
  Agence Nationale de la Recherche

  Award: Metagenopolis grant ANR-11-DPBS-0001
• NN
  National Natural Science Foundation of China

  Awards: NSFC31570116, 81572614, 81772984
• CA
  China Agricultural University
• HE
  Higher Education Discipline Innovation Project

  Award: B18053
• AC
  Aerospace Center Hospital