Severe Acute Respiratory Syndrome Coronavirus 2−Specific Antibody Responses in Coronavirus Disease Patients
Utrecht University · Université Paris Cité · +4 more institutions
Abstract
A new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently emerged to cause a human pandemic. Although molecular diagnostic tests were rapidly developed, serologic assays are still lacking, yet urgently needed. Validated serologic assays are needed for contact tracing, identifying the viral reservoir, and epidemiologic studies. We developed serologic assays for detection of SARS-CoV-2 neutralizing, spike protein-specific, and nucleocapsid-specific antibodies. Using serum samples from patients with PCR-confirmed SARS-CoV-2 infections, other coronaviruses, or other respiratory pathogenic infections, we validated and tested various antigens in different in-house and commercial…
Citation impact
- FWCI
- 40.36
- Percentile
- 100%
- References
- 15
Authors
19- NMNisreen M.A. OkbaCorresponding
Utrecht University, Université Paris Cité, Erasmus MC, German Center for Infection Research, Hôpital Bichat-Claude-Bernard, Charité - Universitätsmedizin Berlin
- MAMarcel A. Müller
Utrecht University, Université Paris Cité, Erasmus MC, German Center for Infection Research, Hôpital Bichat-Claude-Bernard, Charité - Universitätsmedizin Berlin
- WLWentao Li
Utrecht University, Université Paris Cité, Erasmus MC, German Center for Infection Research, Hôpital Bichat-Claude-Bernard, Charité - Universitätsmedizin Berlin
- CWChunyan Wang
Utrecht University, Université Paris Cité, Erasmus MC, German Center for Infection Research, Hôpital Bichat-Claude-Bernard, Charité - Universitätsmedizin Berlin
- CHCorine H. GeurtsvanKessel
Utrecht University, Université Paris Cité, Erasmus MC, German Center for Infection Research, Hôpital Bichat-Claude-Bernard, Charité - Universitätsmedizin Berlin
Topics & keywords
- Serology
- Coronavirus
- Virology
- Antibody
- Immunology
- Medicine
- Pandemic
- Antigen
- Good health and well-being