Cysteine depletion induces pancreatic tumor ferroptosis in mice

Badgley, Michael A.; Kremer, Daniel M.; Maurer, H. Carlo; DelGiorno, Kathleen E.; Lee, Ho‐Joon; Purohit, Vinee; Sagalovskiy, Irina R.; Ma, Alice; Kapilian, Jonathan; Firl, Christina E. M.; Decker-Farrell, Amanda R.; Sastra, Steve A.; Palermo, Carmine F.; Andrade, Leonardo R.; Sajjakulnukit, Peter; Zhang, Li; Tolstyka, Zachary P.; Hirschhorn, Tal; Lamb, Candice; Liu, Tong; Gu, Wei; Seeley, E. Scott; Stone, Everett; Georgiou, George; Manor, Uri; Iuga, Alina C.; Wahl, Geoffrey M.; Stockwell, Brent R.; Lyssiotis, Costas A.; Olive, Kenneth P.

doi:10.1126/science.aaw9872

articleScienceApr 2, 2020GREEN OA

Cysteine depletion induces pancreatic tumor ferroptosis in mice

MAMichael A. Badgley DMDaniel M. Kremer HCH. Carlo Maurer KEKathleen E. DelGiorno HLHo‐Joon Lee

Columbia University Irving Medical Center · University of Michigan · +8 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Ferroptotic cell death and cancer Cell death can occur through different mechanisms, several of which are being explored as potential targets for cancer treatment. One form of cell death that has attracted recent interest is ferroptosis, which is triggered by high intracellular levels of lipid reactive oxygen species. Pancreatic cancer cells have high levels of reactive oxygen species but manage to avoid ferroptosis by importing extracellular cysteine. Studying mice bearing pancreatic tumors, Badgley et al. found that administration of a drug inhibiting cysteine import induced tumor-selective ferroptosis and inhibited tumor growth. Further work will be required to determine whether this therapeutic strategy…

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Topics & keywords

Topics

Keywords

Cysteine
Cancer research
Chemistry
Cell biology
Biology
Biochemistry
Enzyme

UN Sustainable Development Goals

Good health and well-being

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