An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy
Shenzhen University Health Science Center · University of Science and Technology Beijing
Abstract
Abstract The therapeutic effect of reactive oxygen species (ROS)-involved cancer therapies is significantly limited by shortage of oxy-substrates, such as hypoxia in photodynamic therapy (PDT) and insufficient hydrogen peroxide (H 2 O 2 ) in chemodynamic therapy (CDT). Here, we report a H 2 O 2 /O 2 self-supplying nanoagent, (MSNs@CaO 2 -ICG)@LA, which consists of manganese silicate (MSN)-supported calcium peroxide (CaO 2 ) and indocyanine green (ICG) with further surface modification of phase-change material lauric acid (LA). Under laser irradiation, ICG simultaneously generates singlet oxygen and emits heat to melt the LA. The exposed CaO 2 reacts with water to produce O 2 and H 2 O 2 for hypoxia-relieved…
Citation impact
- FWCI
- 30.05
- Percentile
- 100%
- References
- 43
Authors
8- CLConghui LiuCorresponding
Shenzhen University Health Science Center, University of Science and Technology Beijing
- YCYu Cao
University of Science and Technology Beijing
- YCYaru Cheng
University of Science and Technology Beijing
- DWDongdong Wang
University of Science and Technology Beijing
- TXTailin Xu
University of Science and Technology Beijing
Topics & keywords
- Reactive oxygen species
- Photodynamic therapy
- Hydrogen peroxide
- Singlet oxygen
- Chemistry
- In vivo
- Indocyanine green
- Superoxide