Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline

Abstract Background The diagnosis of sarcoidosis is not standardized but is based on three major criteria: a compatible clinical presentation, finding nonnecrotizing granulomatous inflammation in one or more tissue samples, and the exclusion of alternative causes of granulomatous disease. There are no universally accepted measures to determine if each diagnostic criterion has been satisfied; therefore, the diagnosis of sarcoidosis is never fully secure. Methods Systematic reviews and, when appropriate, meta-analyses were performed to summarize the best available evidence. The evidence was appraised using the Grading of Recommendations, Assessment, Development, and Evaluation approach and then discussed by a…

• AT
  American Thoracic Society
• BA
  Brigham and Women's Hospital
• KP
  Kaiser Permanente
• VU
  Vanderbilt University
• UO
  University of Pennsylvania
• OS
  Ohio State University
• SO
  School of Medicine, Boston University
• CC
  Cleveland Clinic
• AU
  Aarhus Universitet
• AU
  Aarhus Universitetshospital
• JH
  Johns Hopkins University
• UO
  University of Cincinnati
• PS
  Pennsylvania State University
• UO
  University of South Carolina
• NJ
  National Jewish Health
• MS
  Morehouse School of Medicine
• SA
  St. Antonius Ziekenhuis
• UO
  University of California, San Francisco