Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China

Although the respiratory and immune systems are the major targets of Coronavirus Disease 2019 (COVID-19), acute kidney injury and proteinuria have also been observed. Currently, detailed pathologic examination of kidney damage in critically ill patients with COVID-19 has been lacking. To help define this we analyzed kidney abnormalities in 26 autopsies of patients with COVID-19 by light microscopy, ultrastructural observation and immunostaining. Patients were on average 69 years (19 male and 7 female) with respiratory failure associated with multiple organ dysfunction syndrome as the cause of death. Nine of the 26 showed clinical signs of kidney injury that included increased serum creatinine and/or new-onset…

• NC
  North Carolina Central University

  Award: 2020kfyXGYJ101
• NN
  National Natural Science Foundation of China

  Awards: 81873602, 81770711, 2017QYTD20, 2020YFC0845700, 81974096, 81570671, 2020kfyXGYJ101, 81873602, 81570671, 81961138007
• MO
  Ministry of Science and Technology of the People's Republic of China
• HU
  Henan University of Science and Technology

  Award: 2017QYTD20
• HU
  Huazhong University of Science and Technology
• NS
  Natural Science Foundation of Hubei Province

  Award: 2017CKB899
• FR
  Fundamental Research Funds for the Central Universities

  Awards: 2020kfyXGYJ101, 2020YFC0845700