Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak

Abstract The novel COVID-19 outbreak has affected more than 200 countries and territories as of March 2020. Given that patients with cancer are generally more vulnerable to infections, systematic analysis of diverse cohorts of patients with cancer affected by COVID-19 is needed. We performed a multicenter study including 105 patients with cancer and 536 age-matched noncancer patients confirmed with COVID-19. Our results showed COVID-19 patients with cancer had higher risks in all severe outcomes. Patients with hematologic cancer, lung cancer, or with metastatic cancer (stage IV) had the highest frequency of severe events. Patients with nonmetastatic cancer experienced similar frequencies of severe conditions…

• NN
  National Natural Science Foundation of China

  Awards: 8197103302, 8197103302/H16
• WU
  Wuhan University
• ZH
  Zhongnan Hospital of Wuhan University
• NI
  National Institutes of Health

  Award: P01HL095489
• MR
  Medical Research Council
• NM
  National Medical Research Council
• NH
  National Heart, Lung, and Blood Institute

  Award: P01HL095489